Choliva 5mg Tablet works by decreasing the production of bile in the liver and promoting the removal of bile from your liver.
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Choliva 5mg Tablet is a medication containing Obeticholic acid, which is classified as a Farnesoid X receptor agonist. It is primarily used to treat a condition called primary biliary cholangitis (also known as primary biliary cirrhosis) in adults. This medication may be prescribed either on its own or in combination with another medicine called ursodeoxycholic acid.
Primary Biliary Cholangitis (PBC) is a chronic liver disorder characterized by the gradual destruction of the bile ducts within the liver. As these bile ducts are damaged and lost, bile, a digestive fluid that helps in the absorption of vitamins and nutrients, accumulates within the liver. This buildup leads to inflammation and scarring, and over time, it can result in cirrhosis. PBC was formerly known as primary biliary cirrhosis.
Here are some key points to note regarding Choliva 5mg Tablet:
Interaction with alcohol is unknown.
Obeticholic Acid is not recommended for use during pregnancy unless absolutely necessary. All the risks and benefits should be discussed with your doctor before taking this medicine.
Obeticholic Acid is not recommended for use while breastfeeding unless absolutely necessary. All the risks and benefits should be discussed with your doctor before taking this medicine.
Choliva 5mg Tablet does not affect your ability to drive. However, you are advised to omit driving if you experience dizziness.
Please consult your doctor if you have kidney impairment or any concerns regarding this.
Dose adjustment may be needed. Please consult your doctor if you have a liver impairment or any concerns regarding this. Inform your doctor if you have/had liver cirrhosis.
Choliva 5mg Tablet works by reducing the production and build-up of bile in the liver and also reduces the inflammation of the liver. Therefore, as a result, it helps to improve liver function.
Common side effects include pruritus, fatigue, stomach pain, discomfort, rashes, joint pain, oropharyngeal discomfort, dizziness, constipation, altered thyroid function, and eczema.
Obeticholic Acid is used to treat several conditions, including:
Obeticholic Acid activates the farnesoid X receptor (FXR), a nuclear receptor found in the liver and gut. FXR plays a critical role in bile acid, inflammatory, fibrotic, and metabolic pathways. FXR activation reduces bile acid concentrations within hepatocytes by limiting de novo cholesterol production and increasing bile acid transport out of hepatocytes. These mechanisms reduce hepatic bile acid exposure and increase choleresis.
Obeticholic Acid should not be used by patients with known hypersensitivity to the medicine or any of its components, as well as those with total biliary obstruction.
There is insufficient human data to establish the drug-associated risk of Obeticholic Acid consumption during pregnancy. Additionally, there is no information on its presence in human milk, its effects on breastfed infants, or its impact on milk production.
Specialized monitoring is required for adverse reactions to the liver, such as pruritus and low-density lipoprotein-cholesterol reduction (HDL-C).
Store Obeticholic Acid at 15°C to 30°C in a dry, light-protected location, and keep it out of children's reach.
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